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What is Glutathione? 

The Power of Glutathione (GSH)

What is it?

How does it improve your health?

Glutathione is a tripeptide (A tripeptide is a peptide consisting of 3 amino acids)

We could get technical here but the essence of the description is it’s a naturally occuring nutrient in the body. It is a non-essential nutrient, but more importantly it is an anti oxidant, preventing damage to important cellular components caused by *reactive oxygen species .It is the bodies most powerful anti-oxidant known and is made by the body. It protects against ageing, infection, cancers, chronic inflammation and many more health issues

*Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. They form as a natural by-product of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. However, during times of environmental stress e.g. heat exposure, exposure to toxins, chemicals, heavy metals, smoking excessive alcohol ROS levels can increase dramatically. And this may result in significant damage to cell structures.

This is known as oxidative stress. In humans, oxidative stress is thought to be involved in the development of  Cancers of most types, Parkinsons Disease,Alzeiheimer's Disease, Atheriosclerosis and heart failure,Sickle Cell Anemia, Autism and Chronic Fatigue Syndrome and  premature aging and many more conditions.

As we get older the levels of glutathione diminishes.It is primarily made by the liver. The more we have in our system the slower we age.If we do not have glutathione in our system we die.

Oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defense, such as glutithione.

The effects of oxidative stress are governed to a large extent by how glutithione overcomes these eruptions in the system and regains its original state.

However, more severe oxidative stress can cause cell death and even moderate oxidation can trigger apoptosis,(programmed cell death) while more intense stresses may cause necrosis (a form of cell injury that results in the premature cell death)

 


Glutathione Functions

Glutathione serves a range of physiologic functions such as protection of cells from oxidative stress, and acts as storage and a transport form of cysteine. Reduced levels compromise cell function, promote tissue damage, and increase morbidity under various disease conditions

Glutathione has multiple functions:

It is the major antioxidant produced by the cells neutralising free radicals and reactive oxygen compounds, as well as maintaining other antioxidants like Vitamins C and E and D.

  • Regulation of the nitric oxide cycle, which is critical for life but can be problematic if unregulated.

  • It is used in metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport, and enzyme activation. Every system in the body can be affected by the state of the glutathione system, especially the immune system, the nervous system, the gastrointestinal system and the lungs.
  • It has a vital function in iron metabolism. Yeast cells depleted of or containing toxic levels of GSH show an intense iron starvation-like response and impairment of the activity of extra-mitochondrial ISC enzymes, followed by death.

Taking Supplements

Taking glutathione orally is not well absorbed across the gastrointestinal tract. And it is not possible to improve glutathione levels this way by taking it orally.

However, it is possible to increase and maintain appropriate glutathione levels by increasing the daily consumption of cysteine-rich foods and/or supplements or by the new discovery of patches applied to the skin surface for regular periods.


Solution

A study was done to investigate the effect of the glutathione patch on organ physiologic function.

Without going into all the clinical reports subjects were instructed to keep well hydrated during the study period. All subjects served as their own control.

The overall data in this study demonstrated that glutathione patches worn 12 hours daily over a period of 4 weeks produced highly significant improvement in physiologic functional status of pancreas, liver, gall bladder, intestines, left and right adrenals, hypothalamus and pituitary gland and very significant improvement in pancreas with a statistical power of at least 72%.

Stated differently all organs achieved significant cellular physiologic functional improvement with a statistical power of at least 91%!

Low Levels and the Consequences

Having low glutathione is also related to deteriorating conditions as seen in cancer, AIDS, sepsis, trauma, burns and even athletic overtraining. By increasing Glutathione it can help improve survival rates in AIDS.

Schizophrenia and bipolar disorder are associated with lowered glutathione. Glutathione (GSH) is the major free radical scavenger in the brain. By replenishing of glutathione using N-acetyl cysteine it has been shown to reduce symptoms of both disorders.

Cancer

Preliminary results indicate glutathione changes the level of reactive oxygen species in isolated cells grown in a laboratory, which may reduce cancer development.

However, once a cancer has already developed, by conferring resistance to a number of chemotherapeutic drugs, elevated levels of glutathione in tumour cells are able to protect cancerous cells in bone marrow, breast, and colon, larynx, and lung cancers. So by using patches this will greatly improve the levels of depleted glutathione in the body in a short time.


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